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Answer Accepted 2 Answers 2 Votes
How sustainable are current water sources—including alternatives such as desalination, wastewater reuse, and groundwater—for supporting irrigated agriculture in semi-arid and arid regions?
Over 80% of water use in semi-arid and arid regions is allocated to agricultural irrigation, making the sustainability of water sources in these areas a critical concern. The key trade-offs and long-term implications of relying on alternative waters sources are not fully understood.
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5 Answers 1 Vote
What is the LOD of polycyclic aromatic hydrocarbons (PAHs)? what is it`s importance in estimation of the hazardous effect of exposure to PAHs?
please explain LOD of PAHs and it`s importance in toxicology
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Answer Accepted 1 Answer 1 Vote
How the drug dosing space and therapeutic level in term of MTD may best be correlated with pharmacokinetics and body metabolic rate in the subject to gain best possible impact and to minimize the toxicity.
when we recommend the dose of antibiotics like oxytetracycline in animals we usually take into consideration the recommended dose on the label but most of the time the therapeutic effect may not be obtained as suspected. As physician we recommend little bit high dose of the drug in some animals for best results which becomes beyond the regulation authorities to justify. Is it possible to recommend the dosing space or dose of the drug flexible including some criteria of considering BMR of the...
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3 Answers 0 Votes
Relationship between PM2.5 exposure and mortality
A recent paper reported a meta-regression analysis of pm2.5 exposure and mortality: : https://www.sciencedirect.com/science/article/abs/pii/S0013935118303256?via%3Dihub Is there a plausible biological mode of action that would support the behavior in the dose-response curve noted in Figure 1?
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Complete 10 Answers 42 Votes
A U.S. government scientist poses the following questions on dose-spacing and the inclusion of "human-relevant" dose groups for toxicity testing purposes ($500 for best answer): $500
Question: Proper dose spacing –Some groups want to test “human-relevant” exposure levels. On the other hand, there are recommendations for testing at doses that assure the compound is being absorbed and some toxicity will be observed. MTD is being criticized for possibly producing nonspecific effects, especially with relatively non-toxic compounds. What is the latest thinking on proper dose spacing that is feasible and functional for regulatory assessments? When should additional dose levels...
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