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12 Answers 3 Votes
Any herbal medicines used for hepatitis, possible mechanism of action, and if possible attached pictures of plants with citations
Any herbal medicines used for hepatitis, possible mechanism of action, and if possible attached pictures of plants with citations
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Answer Accepted 8 Answers 0 Votes
What is the relationship between free radicals and the inflammation process during Chronic diseases?
OxInflammation process is a complex and systemic event that occurs after cellular and tissue injury. The knowledge about both processes is that they coexist, but already known that possibly the inflammatory response is responsible for the generation of a pro-oxidative environment due to the production of Free radicals and Reactive Oxygen species (ROS), especially in chronic diseases. In normal tissue occurs the activation of efficient machinery able to control the oxidative stress, however,...
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Answer Accepted 2 Answers 0 Votes
How can I keep bronchial epithelial cell alive, while retaining the effect of PM exposure?
Objective of the study: Evaluate whether normal bronchial epithelial cells acquire invasiveness following exposure to particulate matter. Initial approach: Expose the BEAS2B cell line to PM10 at concentrations of 50ug and 75ug for 48 hours. Subsequently, perform a wound healing assay and an invasion assay using matrigel. Problem encountered: Post exposure, a significant number of cells died, resulting in inadequate cell viability. This has hindered our ability to observe if the non-malignant...
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Answer Accepted 4 Answers 0 Votes
What is the best way to deplete resident macrophages in the heart?
I am planning studies that require depleting resident macrophages in the heart in a mouse model of myocardial infarction. There are multiple strategies including Csf1r and CD163 antibodies. What is the most specific and effective way to deplete resident cardiac macrophages?
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Answer Accepted 1 Answer 1 Vote
How the drug dosing space and therapeutic level in term of MTD may best be correlated with pharmacokinetics and body metabolic rate in the subject to gain best possible impact and to minimize the toxicity.
when we recommend the dose of antibiotics like oxytetracycline in animals we usually take into consideration the recommended dose on the label but most of the time the therapeutic effect may not be obtained as suspected. As physician we recommend little bit high dose of the drug in some animals for best results which becomes beyond the regulation authorities to justify. Is it possible to recommend the dosing space or dose of the drug flexible including some criteria of considering BMR of the...
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