what are the possible side effects of the use of 5 alpha reductase inhibitors in young men?

Question

what is the incidence of side effects?
what are the common side effects and symptoms?
what are the genetics and molecular bases for such side effects and symptoms?

Basma Marghani · Answer

Finasteride, one of the most prescribed medicines for BPH, is a steroid inhibitor of 5α–reductase type 2 that inhibits testosterone conversion to DHT. However, finasteride has been linked to several negative side effects, including erectile dysfunction, depression, libido loss , male infertility, poor seminal quality, and ejaculation disorders.

https://doi.org/10.1016/j.lfs.2023.121747

https://doi.org/10.1016/j.lfs.2023.121747

ashokbiotech · Answer

SRD5A2 inhibitors like finasteride and Dutasteride can cause side effects. Side effect could include sexual dysfunction, decreased libido, erectile dysfunction, and reduced ejaculatory volume. Depression, anxiety, and mood. Clinical side effects include gynecomastia, testicular pain, and hormonal imbalances. Skin issue like rash or itching are also possible.

Fatima Abubakar I · Answer

Possible side effects of 5 alpha reductase 
5 alpha reductase such as Finasteride and dutasteride lowers dehydrotestosterone DHT, which is important for sexual and other functions. Because of this, young men may experience the following:
-        Reduced sex drive or erectile problems
-        Less semen volume or delayed ejaculation
-        Breast tenderness or enlargement
-     Mood changes like low mood or anxiety and
-   Rarely, symptoms that continue even after stopping (post-finasteride syndrome)
2. These effects occurs with
-  Sexual issues occuring around 2–10% of men
- Breast changes about 1%
- Mood changes with exact rate unknown, but has been reported
- Persistent symptoms, uncommon, but still debated
3. Most common symptoms include the following:
Low libido, erection difficulties, smaller ejaculate volume, occasional testicular pain, and sometimes mood or concentration problems.
4. These effects occur due to
-        Lower DHT : weaker androgen receptor activity in tissues like prostate, skin, and sexual organs
-        Blocked neurosteroid production which may affect brain pathways linked to mood and anxiety
-        Genetic differences in the SRD5A2 or androgen receptor genes may make some men more sensitive
-        Possible epigenetic changes could explain why a few men have lasting effects

what are the possible side effects of the use of 5 alpha reductase inhibitors in young men?

Post an Answer

Basma Marghani

ashokbiotech

Is Oxidative Stress sufficient by itself as an indicator and compelling basis for a carcinogenic concern?

What are recent machanism of actions, minmum duration of years of heat exposure and minimum temperature required for various heat induced skin cancers, also opnion for Kangri Cancer to be answered

In austere/conflict settings, when does a complex surgery become ethically unjustifiable due to a lack of postoperative resources for managing complications?

Why are ambitious, planet-critical research proposals, still hitting funding roadblocks, and what will it take to break down these barriers before it’s too late?

For a change in the peer-reveiwing as an urgent need?

Type

Status

Bounty

Created

Answer Count

Vote Count

Creator

Tags

Share Page

Copy URL to Clipboard

what are the possible side effects of the use of 5 alpha reductase inhibitors in young men?

Post an Answer

Basma Marghani

ashokbiotech

Is Oxidative Stress sufficient by itself as an indicator and compelling basis for a carcinogenic concern?

What are recent machanism of actions, minmum duration of years of heat exposure and minimum temperature required for various heat induced skin cancers, also opnion for Kangri Cancer to be answered

In austere/conflict settings, when does a complex surgery become ethically unjustifiable due to a lack of postoperative resources for managing complications?

Why are ambitious, planet-critical research proposals, still hitting funding roadblocks, and what will it take to break down these barriers before it’s too late?

For a change in the peer-reveiwing as an urgent need?

Type

Status

Bounty

Created

Answer Count

Vote Count

Creator

Tags