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4 Answers 2 Votes
Snail mucous has many advantages, what is the best way to extract it without changing its composition?
-land snails like Eremina desertorum, how can i get its mucous without killing or hurt it
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Answer Accepted 1 Answer 1 Vote
Can Levodopa and Renin-angiotensin system alter the intercellular tight junction (TJ) proteins in the epithelial cells in colorectal adenocarcinoma cell line (in vitro)?
Colorectal adenocarcinoma cell line (Caco-2) express tight junctions from 17-21 days. Levodopa is the precursor of dopamine, a well-known neurotransmitter, owever it also porduce effect in the gut. The renin-angiotensin system is responsible for maintaining homeostais and regulate blood pressure and volume.
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7 Answers 1 Vote
Can we consider that epidrugs can constitute a good therapeutic strategy against cancer diseases?
Recently, it has been demonstrated that epigenetic perturbations are mainly involved in cancer development. Can we consider that epidrugs can constitute a good therapeutic strategy against cancer diseases ?
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Answer Accepted 4 Answers 1 Vote
What conference(s) do you find most useful for pharmacovigilance related topics?
Which conference(s) are best for learning, networking and presenting on pharmacovigilance?
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Answer Accepted 4 Answers 0 Votes
What is the best way to deplete resident macrophages in the heart?
I am planning studies that require depleting resident macrophages in the heart in a mouse model of myocardial infarction. There are multiple strategies including Csf1r and CD163 antibodies. What is the most specific and effective way to deplete resident cardiac macrophages?
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3 Answers 0 Votes
What are the best ways to handle Hawthorne and John Henry effects in a randomized control trials?
What are the best ways to handle Hawthorne and John Henry effects in a randomized control trial where agricultural extension messages are applied to increase consumption of organic vegetables in rural Nigeria
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Answer Accepted 1 Answer 1 Vote
How the drug dosing space and therapeutic level in term of MTD may best be correlated with pharmacokinetics and body metabolic rate in the subject to gain best possible impact and to minimize the toxicity.
when we recommend the dose of antibiotics like oxytetracycline in animals we usually take into consideration the recommended dose on the label but most of the time the therapeutic effect may not be obtained as suspected. As physician we recommend little bit high dose of the drug in some animals for best results which becomes beyond the regulation authorities to justify. Is it possible to recommend the dosing space or dose of the drug flexible including some criteria of considering BMR of the...
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